Recombinant Insulin-like Growth Factor-1 (OsrIGF-1)

OsrIGF-1 LR3, Recombinant Insulin-like Growth Factor-1

 

Insulin-like growth factor-1 (IGF-1) is a hormone similar in molecular structure to insulin. It primarily functions through binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R). IGF-1 is one of the most potent natural activators of the AKT signaling pathway, which stimulates cell growth and proliferation, and inhibits cell apoptosis. LR3 IGF-1 (Long Arg3 IGF-1) is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. The LR3 IGF-1 has much higher stability and biological activity. 

【Source】:Rice   Grain (Oryza Sativa)
【Catalog   Number】:HYC007M01
【Formulation】:It is lyophilized with mannitol as the stabilizer.
【Package size】:50ug, 1mg, 10mg
【Endotoxin】:Less than 5EU/mg
【Physical Appearance】:White lyophilized powder 
【Purity】:More than 95% as determined by SDS-PAGE. 

Molecular Weight: 8.3kD

 

Biological activity: The bioactivity determined by a cell proliferation assay using Bal B/C 3T3 cell, corresponding to a specific activity of ≥ 1×10Units/mg.

 

Applications:

Mammalian cell culture

Cosmetic and beauty care

Healthcare products

 

Storage and Handling:

Stored at temperatures -20℃ for at least 24 months. It is recommended to reconstitute LR3 IGF-1 at 100-200ug/ml in sterile water. Further dilutions can be made in other aqueous buffer. Use as soon as possible after opening. Please avoid freeze-thaw cycles.

 

FOR RESEARCH, LABORATORY AND MANUFACTURE USE ONLY. NOT INTENDED FOR DIRECT USE ON HUMANS.

 

1.Bioactivity

The stimulating cell proliferation of OsrIGF-1 measured using the Balb/c 3T3 cell line. The ED50  of OsrIGF-1 is less than 1ng/ml.  

 

2. Comparison of stimulating cell proliferation with other vendors

 

Comparison of stimulating ability of OsrIGF-1 with other vendors in nine days. 

 

3. Comparison of performance in stimulating cell proliferation over generations with another vendor

Comparison of stimulating cell proliferation activity of OsrIGF-1 with another vendor in four generations. 

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